Reliable, rapid chromatographic immunoassay for the qualitative detection of nucleocapsid antigen present in human nasale samples



Convenient sampling, rapid results.

Vous lisez ce: Test pcr une ou deux narines

the SARS-CoV-2 rapid Antigen audit Nasal provides rapid results à la fast decision make at the mission of Care. Nez sampling is much less invasive, which deserve to reduce padura discomfort, and minimize the duration de the procedure as well ont the risk ns sneezing jaune coughing. Nasal swab samples may be self-collected de patients under supervision, supplying further cacher for health care professionals.


An assist in identifying people infected de SARS-CoV-215


The SARS‑CoV‑2 quick Antigen audit Nasal is a fast chromatographic immunoassay à la the qualitative detection de SARS‑CoV‑2 nucleocapsid antigen present in human nasal samples.

This test is intended venir detect antigen indigenous SARS‑CoV‑2 in individuals suspected du COVID‑19 or with known jaune suspected exposure to SARS‑CoV‑2. This product is intended pour professional use in activities and alloue of treatment environments, or self-collection under auto supervision ns a healthcare worker.

SARS-CoV-2: an overview of germes structure, transmission and detection


Severe Acute respiratory tract Syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, single-stranded RNA virus of auto family Coronaviridae. Coronaviruses share structural similarities et are composed of 16 nonstructural proteins et 4 structural proteins: pic (S), envelope (E), membrane (M), and nucleocapsid (N). Coronaviruses cause première diseases with symptoms varying from those de a mild common cold à more severe ones such oui Coronavirus an illness 2019 (COVID-19) caused passant par SARS-CoV-2 1,2. 

SARS-CoV-2 is transmitted indigenous person-to-person primarily dessus respiratory droplets, if indirect dévolution through contaminated surfaces is also possible3-6. The germes accesses host cells via the angiotensin-converting enzyme 2 (ACE2) receptor, which is most abundant in thé lungs7,8.

The incubation period pour COVID-19 arrays from 2 - 14 days adhering to exposure, with most des boites showing symptoms about 4 - 5 work after exposure3,9,10. Thé spectrum of symptomatic infection ranges native mild (fever, cough, fatigue, loss de smell and taste, shortness de breath) venir critical11,12. While many symptomatic caisse are not severe, severe disease occurs mostly in adults through advanced âge or underlying clinical comorbidities et requires extensive care. Acute respiratory distress syndrome (ARDS) is a surtout complication in patient with major disease. Critical cases are characterized de e.g., respiratory failure, shock and/or multiple body organ dysfunction, or failure11,13,14. 

Definite COVID-19 diagnosis entails directement detection du SARS-CoV-2 RNA par nucleic acid amplification technology (NAAT)21-23. Serological assays, i m sorry detect antibodies versus SARS-CoV-2, deserve to contribute à identify individuals, which were previously infected de the virus, et to assess the extent de exposure de a population. They can thereby help venir decide nous application, enforcement jaune relaxation de containment measures24.

Upon infection with SARS-CoV-2, auto host mounts année immune réagir against thé virus, including opération of specific antibodies against viral antigens. Both IgM and IgG have been detected oui early as day 5 after symptom onset25,26. Median oan has to be observed at job 10 - 13 for IgM and day 12 - 14 for IgG27-29, while très levels have been report at la semaine 2 - 3 à la IgM, week le 3 - 6 for IgG and week 2 parce que le total antibody25-31. Vice versa, IgM seems venir vanish around la semaine 6 - 732,33, high IgG seropositivity is watched at the time25,32,33. When IgM is frequently the surtout antibody class secreted to du sang in the early stages de a primary antibody response, levels et chronological order du IgM and IgG antibody appearance seem venir be highly variable pour SARS-CoV-2. Anti-SARS-CoV-2 IgM et IgG often show up simultaneously, and some cases have to be reported whereby IgG appears avant IgM, limiting its diagnostic utility26,27,29,34,35. 

After infecter or vaccination, auto binding strength du antibodies venir antigens rises over temps - a process called affinity maturation36. High-affinity antibodies deserve to elicit neutralization de recognizing and binding details viral epitopes37,38. In SARS-CoV-2 infection, antitoxin targeting both auto spike and nucleocapsid proteins, which correlate v a solid neutralizing response, are formed oui early as day 9 onwards, saying seroconversion peut être lead to abrite for at the very least a limite time34,39-42.


The benefit de having a SARS-CoV-2 antigen audit available


The SARS-CoV-2 germe causes respiratory tract tract infection. It is sent mainly passant par respiratory droplets after close contact, and primary viral replication is presumed à occur in mucosal epithelium du the top respiratory street (nasal cavity et pharynx).1 At these locations viral load peaks within the life week after symptom onset, et then declines.2

A SARS-CoV-2 antigen audit detects auto presence of the SARS-CoV-2 virus from part de the upper respiratory street swab specimens by identifying a nucleoprotein the is carried by the virus. The juge identifies current personne infectée during the acute phase du COVID-19, when the germe is still present in super quantities in auto respiratory tract.

At slaveslutlisa.com slaveslutlisa.com conditions météorologiques believe wide accessibilité to together high-performance, instrument-free and reliable alloue of Care tests can contribute substantially to better managing thé ongoing pandemic crisis.


Features et benefits de the SARS-CoV-2 rapid Antigen test Nasal


In to compare to thé existing slaveslutlisa.com SARS-CoV-2 quick Antigen Test, thé SARS-CoV-2 quick Antigen audit Nasal collects the sample from thé front area of the nose instead de the nasopharynx, leading to a simplified and faster trial and error procedure.1 This testing method can help reduce overall padura discomfort, an especially in sensitive individuals such ont children, elderly personnes and/or people with disabilities.

Besides being much less invasive, the test also provides patient with the loption to self-collect their nasal sample under thé supervision ns a medical care professional. Through diminished physical contact, this method de testing have the right to help à decrease the risk du exposure to the virus for healthcare professionals. Even if it is the test could likewise be supplied without supervision ns a healthcare professional will depend on local regulatory requirements.


The benefits du the SARS-CoV-2 rapid Antigen audit Nasal in short:


Using a nez swab for quick et convenient specimen collectionGetting a quick an outcome within 15-30 minutes – no need pour a follow-up appointment venir discuss auto resultProviding patients with the option to self-collect their nasale sampleAllowing decentralized testing jaune access à testing in locations where laboratory experimentation is no available


Insert the sterile swab into the nostril with thé most secretion. While rotating thé swab, insert auto swab 2 centimètre (slightly less than 1 inch) parallel to auto palate (not upwards) towards auto throat into thé nostril until resistance is endroit at turbinates. Faire not apply pressure. 

Rotate the swab 4 times for about 15 seconds versus the nasale wall et remove cette from auto nostril.


Repeat action 1a. With thé same swab in the divers nostril.

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Note: Samples have to be accumulated from both nostrils using the same swab.


Insert the swab into an extraction buffer tube. When squeezing the buffer tube, stir auto swab more than 10 times.


Remove thé swab when squeezing thé sides de the rus to extract the liquid from thé swab.

WARNING! Failure à squeeze the roques can lead to imprécisions results périmé to overabundance buffer in thé swab.


Place the juge device nous a level surface and apply 4 drops of extracted sample at a 90º angle to the specimen well of the test device.


Read the juge result at 15 à 30 min.

WARNING! danger of incorrect results. Do not check out the juge result after 30 min.


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A fancy line appears in auto top section de the result window to montrer that the juge is working properly. This is auto control heat (C). Even si the control line is faint, the test should be considered to have been perform properly. Si no control line is montrer clairement the test is invalid. 

In case of a positif result, a fancy line appears in thé lower section of the result window. This is the audit line (T). Even si the audit line is an extremely faint or not uniform, the test result have to be interpreted oui a positif result.